Diablo IV Alchemy Guide

Last Update: June 1, 2023

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Diablo IV Alchemy Guide header.
 

Potions and other consumables are a constant necessistiy in Diablo IV, but they don't work exactly the same as they did in previous Diablo titles. Follow our Diablo IV Alchemy Guide to find out more. 

Want to know what content is worth doing once you've increased your World Tier? Check out our guides on Nightmare DungeonsHelltide, and Whispers of the Dead. We also cover how you should be upgrading your gear and the Paragon system.

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Diablo IV Alchemy Materials

Alchemy materials in Diablo IV are primarily found throughout the open world, via plants that you can interact with. These respawn relatively frequently, and are always worth gathering when on the move to your next quest or dungeon. Some sidequests will also reward you with caches containing an assortment of materials, good if you're not going out of your way to explore.

If you have an abundance of a certain material, then it's possible to refine them into a different one at an Alchemist. This can only be used to obtain Magic rarity materials, and you must still gather rarer ones normally.

How Unlock Stronger Potions in Diablo IV

Healing potions have been changed once again for Diablo IV. While you still have a recharging pool of potions (5 to start with, 9 after increasing your Renown in each region), you must now upgrade your healing potion's effectiveness at an Alchemist. All potions restore a certain amount of life instantly, along with an extra 35% of your max life over 3 seconds.

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Name Materials Needed Level Needed Effect
Weak Healing Potion N/A 1 Heal 17 HP instantly, plus 35% of Max HP over 3 seconds.
Tiny Healing Potion 2 Gallowvine. 10 Heal 48 HP instantly, plus 35% of Max HP over 3 seconds.
Minor Healing Potion 15 Gallowvine, 5 Biteberry, 400 Gold. 20 Heal 80 HP instantly, plus 35% of Max HP over 3 seconds.
Light Healing Potion 20 Gallowvine, 10 Biteberry, 5 Crushed Beast Bones, 470 Gold. 30 Heal 141 HP instantly, plus 35% of Max HP over 3 seconds.
Moderate Healing Potion 20 Gallowvine, 12 Howler Moss, 5 Demon's Heart, 900 Gold. 45 Heal 255 HP instantly, plus 35% of Max HP over 3 seconds.
Strong Healing Potion 27 Gallowvine, 15 Reddamine, 5 Paletongue, 1,700 Gold 60 Heal 378 HP instantly, plus 35% of Max HP over 3 seconds.
Greater Healing Potion 36 Blightsbane, 18 Lifesbane, 5 Grave Dust, 5 Angelbreath, 2,500 Gold. 70 Heal 559 HP instantly, plus 35% of Max HP over 3 seconds.
Major Healing Potion 10 Angelbreath, 27 Reddamine, 27 Biteberry, 27 Blightsbane, 27 Lifesbane, 27 Howler Moss, 5 Fiend Rose, 5,000 Gold. 80 Heal 827 HP instantly, plus 35% of Max HP over 3 seconds.
Superior Healing Potion 10 Forgotten Soul, 20 Angelbreath, 10 Fiend Rose, 20 Grave Dust, 36 Blightsbane, 20 Demon's Heart, 36 Howler Moss, 12,500 Gold. 90 Heal 1,274 HP instantly, plus 35% of Max HP over 3 seconds.

Diablo IV Elixirs

Alchemists can also make Elixirs, consumables that grant you buffs for 30 minutes. All Elixirs also grant 5% bonus experience, so it's worth having one active at all times.

Diablo IV Elixir List

Name Materials Needed Level Needed Effect
Weak Iron Barb Elixir 5 Gallowvine, 5 Biteberry, 1,000 Gold 5 Increases Armor by 50, Thorns by 25, and Experience by +5% for 30 minutes.
Weak Third Eye Elixir 8 Gallowvine, 5 Howler Moss, 1,000 Gold 10 Increases Dodge by 4% and Experience by +5% for 30 minutes.
Weak Elixir of Shadow Resistance 10 Gallowvine, 6 Brightshade, 1,000 Gold 15 Increases Shadow Resist by 15% and Experience by +5% for 30 minutes.
Weak Elixir of Poison Resistance 10 Gallowvine, 6 Howler Moss, 1,000 Gold 15 Increases Poison Resist by 15% and Experience by +5% for 30 minutes.
Weak Elixir of Lightning Resistance 10 Gallowvine, 6 Reddamine, 1,000 Gold 15 Increases Lightning Resist by 15% and Experience by +5% for 30 minutes.
Weak Elixir of Fire Resistance 10 Gallowvine, 6 Lifesbane, 1,000 Gold 15 Increases Fire Resist by 15% and Experience by +5% for 30 minutes.
Weak Elixir of Cold Resistance 10 Gallowvine, 6 Biteberry, 1,000 Gold 15 Increases Cold Resist by 15% and Experience by +5% for 30 minutes.
Weak Assault Elixir 12 Gallowvine, 6 Lifesbane, 1,000 Gold 20 Increases Attack Speed by 7% and Experience by +5% for 30 minutes.
Weak Crushing Elixir 12 Gallowvine, 4 Howler Moss, 1,000 Gold 25 Increases Overpower damage by 20% and Experience by +5% for 30 minutes.
Weak Precision Elixir 15 Gallowvine, 5 Blightshade, 1,000 Gold 30 Increases Critical Strike Chance by 2%, Critical Strike Damage by 15%, and Experience by +5% for 30 minutes.
Weak Acrobatics Elixir 15 Gallowvine, 1 Angelbreath, 1,000 Gold 35 Reduces Evade Cooldown by 8% and Experience by +5% for 30 minutes.
Iron Barb Elixir   35 and Experience by +5% for 30 minutes.
Elixir of Undead-Slaying   36 and Experience by +5% for 30 minutes.
Elixir of Man-Slaying   36 and Experience by +5% for 30 minutes.
Elixir of Demon-Slaying   36 and Experience by +5% for 30 minutes.
Elixir of Beast-Slaying   36 and Experience by +5% for 30 minutes.
Third Eye Elixir   40 and Experience by +5% for 30 minutes.
Elixir of Shadow Resistance   45 and Experience by +5% for 30 minutes.
Elixir of Poison Resistance   45 and Experience by +5% for 30 minutes.
Elixir of Lightning Resistance   45 and Experience by +5% for 30 minutes.
Elixir of Fire Resistance   45 and Experience by +5% for 30 minutes.
Elixir of Cold Resistance   45 and Experience by +5% for 30 minutes.
Strong Iron Barb Elixir   50 and Experience by +5% for 30 minutes.
Assault Elixir   50 and Experience by +5% for 30 minutes.
Strong Third Eye Elixir   55 and Experience by +5% for 30 minutes.
Crushing Elixir   55 and Experience by +5% for 30 minutes.

Diablo IV Incense 

Unlike the previous alchemy creations, Incense can be used to buff multiple people at once. All Incense will apply a 20 minute buff to every nearby player, meaning you can use it to help other players even when you're in the open world. Incenses come in types, and only one of each type can be active at a time.


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Release Date
June 6, 2023 (Calendar)
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Action RPG
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